Journal of Drug Research in Ayurvedic Sciences

Register      Login

Table of Content

2019 | July-September | Volume 4 | Issue 3


Prof Vaidya Kartar Singh Dhiman

Establishment of National Raw Drug Repository (NRDR): A CCRAS Initiative

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:1] [Pages No:00 - 00]

PDF  |  DOI: 10.5005/jdras-4-3-iv  |  Open Access |  How to cite  | 

Original Article

Santosh S Mane, Thekkekkootthumughath P Sinimol, Pravin R Masram, Chinmay Rath, Bonthu Susmitha, Sugriv K Gaur, Ashish Kumar Tripathi, Mayur Y Kamble, Joseph GV Rattna

Observation on Single-plant Therapy (Ekala Dravya Chikitsa) among Folk Healers of Andaman and Nicobar Islands, India

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:10] [Pages No:103 - 112]

Keywords: Andaman and Nicobar, Ekala Dravya Chikitsa, Medicinal plant, Tribes

PDF  |  DOI: 10.5005/jdras-10059-0074  |  Open Access |  How to cite  | 


Introduction: The collection and documentation of folklore claims of the native population of Andaman and Nicobar Islands including tribes are very essential as these claims can pave the path for new drug discovery. The concept of treating a disease by using a single plant or utilizing it as health supplements are rapidly spreading all over the world and it is widely practiced by physicians. Objectives: This study sought to document the distinct plant species used in treatment by the native and tribes of Andaman and Nicobar Islands, India. Materials and methods: During the year 2013 to 2016, a total of 23 periodical surveys of 75 forest beats of Andaman and Nicobar Islands were conducted and 62 local traditional folk healers were interviewed as per the questionnaire based on ethnomedicinal, survey protocol. Observations: One hundred and forty-one folklore claims related to single-herbal remedies were registered which comprises 103 medicinal plant species used to treat 47 different diseases. Maximum numbers of species, i.e., 13 are utilized to cure abdominal pain followed by 12 species for headache and 11 species for fever. Discussion: Among the 103 plant species, 85 species have been quoted in the texts of Ayurveda and the remaining 18 plants have been also defined as folk medicine in other literature of plant studies. However, this study highlights their utilization in common disease by the native and tribal folk healers of Andaman and Nicobar Islands. Conclusion: This study gives immense output on the use of the individual medicinal plant in varied systemic and local diseases from the folk healers of the Andaman and Nicobar Islands. Organized and constructive information incorporated in this article may aid in conducting further pharmacological, toxicological, and clinical studies on reported claims to confirm their therapeutic efficacy and utility.

Original Article

Kishor P Patel, Chandrashekhar Jagtap, Mukesh Nariya, Biswajyoti Patgiri, Soma N Murthy, Pradeepkumar Prajapati

Evaluation of Antihyperglycemic and Hypoglycemic Activities of Shadguna Makaradhwaja and Guduchi Ghana in Swiss Albino Mice

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:6] [Pages No:113 - 118]

Keywords: Ayurved, Diabetes mellitus, Herbomineral, Makaradhwaja, Rasashastra

PDF  |  DOI: 10.5005/jdras-10059-0076  |  Open Access |  How to cite  | 


Background: Diabetes mellitus (DM) is a group of metabolic disorders which share the common phenotype of hyperglycemia that occurs due to defects in insulin secretion, insulin action, or sometimes both. Herbomineral formulations can be the alternative for contemporary synthetic oral hypoglycemic agents due to their potency, suitability, and negligible side effects. Makaradhwaja is one of those potent antidiabetic drugs used in Ayurved. Objectives: To evaluate the hypoglycemic and antihyperglycemic activity of Shadguna Makaradhwaja (SM) formulations prepared by Swarna Varkha (SMV) and from residue Apakwa Talastha Swarna powder (SMR) with Guduchi Ghana (GG) in Swiss albino mice. Materials and methods: Oral glucose tolerance test and 18 hours fasted mice model were used. Shadguna Makaradhwaja with GG (5.85:94.15 ratios) was administered with honey at a dose of 65 mg/kg. Glibenclamide (GB; 0.65 mg/kg) was used as the standard drug. Results: In hypoglycemic study, SMV showed 18.2, 27.83, 34.88, and 47.41%, while SMR showed 4.85, 20.52, 29.70, and 44.3% reduction in blood sugar level (BSL) at 1, 2, 3, and 5 hours, respectively. In antihyperglycemic study, SMV showed 81.73, 49.23, 14.8, and 0% and SMR showed 56.38, 42.23, 1.16, and 21.58% reduction in BSL at 30, 60, 90, and 120 minutes, respectively. Both results were statistically significant when compared to the control group. Conclusion: Test drugs showed significant hypoglycemic and antihyperglycemic effects as compared to the control group. SMV showed more hypoglycemic effect, while SMR showed better antihyperglycemic effect.

Original Article

Raghavendra Naik, Shashidhar H Doddamani, V Rama Rao, N Shiddamallayya, Amit K Dixit, Chinmay Rath, Anupam K Mangal

Documentation of Local Health Traditions of Yadgir District, Karnataka

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:7] [Pages No:119 - 125]

Keywords: Ayurveda, Folk claim, Local health traditions, Medicinal plants

PDF  |  DOI: 10.5005/jdras-10059-0077  |  Open Access |  How to cite  | 


Aim: The traditional medicinal practice in India includes different aspects of health such as prevention, promotion, and healing. Since there is need for documenting this traditional medicinal practice prevalent in different parts of the country for the preservation of the knowledge, the present study was undertaken to record the traditional knowledge of medicine from Yadgir district of Karnataka. Materials and methods: A Medico-Ethno Botanical survey was undertaken in the Yadgir district of Karnataka between September and December 2017. Data were collected from traditional healers and locals by means of personal interviews using a prescribed format. Results: A total of 20 folk claims used for the treatment of 16 different disease conditions were recorded. The remedies were mostly prepared in the form of decoction, paste, poultice, juice, etc. and were mainly taken orally. Eczema, paralysis, toothache, wound obesity, diabetes, fever, jaundice, fracture, cough, anemia etc. are some of the diseases usually treated by traditional practitioners. Only single ingredient was used in 16 documented claims whereas remaining 4 are compound preparations having more than one ingredient. It is observed that, most of the medicinal plants are used in fresh form, after collecting from their natural habitat whenever necessary. Conclusion: Since the documentation of traditional knowledge on medicinal uses of plants is vital for the future generation, this study could serve an important role in fulfilling this purpose. Clinical significance: The documented data can also serve as a base for the development of new medicines by scientific studies.


Arun M Gurav, Archana G Mhase, Rekha R Nirawane, Rasika Kolhe, Penchala P Goli, Anupam K Mangal

Multiplication of Bharangi—Clerodendrum serratum (L.) Moon: An Ayurvedic Important Plant

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:6] [Pages No:126 - 131]

Keywords: Conservation, Growth regulators, In vitro propagation, Micropropagation, Node

PDF  |  DOI: 10.5005/jdras-10059-0078  |  Open Access |  How to cite  | 


Aim: To develop effective in vitro multiplication protocol for rare and endangered medicinal plants of Clerodendrum serratum (L.) Moon. Materials and methods: Trials were carried out using nodal segments as explants, which were inoculated on Murashige and Skoog medium (MS) plain medium and different concentrations of phytohormones viz., benzylaminopurine (BAP), kinetin (Kn), indol-3-butyric acid (IBA), indol-3-acetic acid (IAA), and naphthaleneacetic acid (NAA), and incubated for 8 hours of photoperiod using cool- white fluorescent tubes with a light intensity of 3,000 lux at 22°C + 2°C. Results: The maximum (7.0 ± 0.045) numbers of shoots were developed from the nodal segment inoculated on MS fortified with BAP (4 mg/L) ± 0.1 % polyvinylpyrrolidone (PVP) with shoots of 1.72 ± 0.018 cm height. Auxin BAP at 4 mg/L proved to be effective for bud proliferation and production of multiple shoots. The best and early root induction was achieved on MS + IBA (1–4 mg/L). Conclusion: The developed in vitro protocol would be beneficial for the fast multiplication of bharangi plants and help to minimize the burden on supply and demand, so that the huge demand for the drug is fulfilled and also helpful to protect the plant.


Nilima N Wadnerwar, Dhiraj Singh Rajput, Akhilesh A Deshmukh, Apurva Gaikwad

A Critical Review on Haratala (An Arsenical Compound)

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:6] [Pages No:132 - 137]

Keywords: Avasthika Rasayana, Critical review, Dhatu visha, Haratala, Marana, Shodhana

PDF  |  DOI: 10.5005/jdras-10059-0068  |  Open Access |  How to cite  | 


Background: Haratala is described as the Dhatu visha and it contains arsenic and sulfur. Arsenic is a heavy metal that may lead to acute or chronic heavy metal toxicity. Although Haratala is effective and popular as Rasamanikya, it is not used as Rasayana or therapeutic drug in routine practice either in pure or in Bhasma form. It is used as a main drug or an auxiliary drug to prepare formulation. Aim: To focus on the various utilities of Haratala, so that it can be safely used in the clinical practice in a wide range of indications. Review results: In the literature available, it is observed that along with therapeutic utility of Haratala, Haratala Bhasma is used as Rasayana. But arsenic present in Haratala may cause toxicity if shodhana and marana of Haratala are not conducted properly. It is observed from the previous research that shodhana may enhance the synergistic effect of Haratala in cellular apoptosis for the treatment of leukemia. Marana may provide safer bioassimilability before their use in most of the formulations in which it may act as an antagonist and subside the toxicity of the formulations. Conclusion: Haratala Bhasma is indicated in various disease conditions. Hence, it can be used as Avasthika Rasayana. But during its use, safety of the drug should be ensured by following proper shodhana and marana procedures. Clinical significance: Studies should be conducted to observe its efficacy in healthy individuals as Rasayana and in patients of acute promyelocytic leukemia (APL) as an adjuvant drug.


Vivek K Patel, Rabinarayan Acharya, Bhupesh R Patel

A Comprehensive Review of Karavīra: A Familiar Plant as Depicted in Classical Texts of Āyurveda

[Year:2019] [Month:July-September] [Volume:4] [Number:3] [Pages:19] [Pages No:138 - 156]

Keywords: Aśvamāra, External uses, Internal uses, Nerium oleander, Poisons, Thevetia peruviana, Upavisa

PDF  |  DOI: 10.5005/jdras-10059-0071  |  Open Access |  How to cite  | 


Background: Karavīra, though considered as Upvisa, has been a part of Ayurvedic pharmacopoeia for treating many diseases. As a drug, karavīra and its various parts have been utilized in different dosage forms against various disease conditions through external and internal application. Classical texts are written at different time periods, since the origin of Āyurveda. These information have not been critically reviewed and published in a compiled format. A systematic review regarding the identification and use of this classical drug is the need of time. Aim: To have a comprehensive review on karavīra like classification, synonyms, pharmacological properties, actions, varieties, and formulations containing karavīra or its parts as an ingredient from different classical texts and to present them in a systematic manner. Results: After review, different opinions are found about the types of karavīra based on their flower color. Various synonyms are attributed to describe its morphological as well as pharmacological characters. Ayurvedic classics classified karavīra in varga based on various criteria. Karavīra has been used as an ingredients in 222 formulations having external and internal uses. Nerium oleander L. and Thevetia peruviana (Pers.) K. Schum. are source plants of karavīra reported for their therapeutic value and various pharmacological activities. All parts of these plants are having toxic properties because of their phytoconstituents present in them. Conclusion: Karavīra described in classical texts of Āyurveda by using various synonyms, their varieties, varga, their rasapañcaka, karma, and a wide range of therapeutic importance in 222 formulations to combat 62 diseased conditions. Maximum formulations are indicated in the treatment of Kustha. Maximum dosage forms are Taila. External application of karavīra are found more as compared to internal application, which may be due to its poisonous character.