Journal of Drug Research in Ayurvedic Sciences

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2017 | July-September | Volume 2 | Issue 3

ORIGINAL ARTICLE

Shivani Ghildiyal, Apurva Joshi, Vinod K Joshi

Comparative Study on Two Variants of Laghupanchamula (A Compound Ayurvedic Formulation) for Important Groups of Phytochemicals and Antioxidant Activity

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:7] [Pages No:157 - 163]

PDF  |  DOI: 10.5005/jp-journals-10059-0015  |  Open Access |  How to cite  | 

Abstract

Introduction

Laghupanchamula is a compound formulation prepared by combinations of roots of five herbs. Two variants of Laghupanchamula have been described in Ayurvedic classics where beside four common herbs fifth one is either Gokshura (Tribulus terrestris L.) or Eranda (Ricinus communis L.). The objective of the study is to make comparison between two variants of Laghupanchmula with respect to important group of phytochemicals and antioxidant activity to corroborate the science behind their therapeutic utility.

Materials and methods

Standard methods have been followed for quantitative determination of total quantity of phenols, tannins, flavonoids, and flavonols, and in vitro antioxidant activity in variants of Laghupanchmula formulations. Qualitative high-performance liquid chromatography (HPLC) analysis has also been performed to establish presence/absence of important chemical constituents in formulations.

Results

Additional quantity of phenols, tannins, flavonoids, and flavonols has been observed in Laghupanchamula variant containing Eranda than the variant containing Gokshura. Greater antioxidant activity has also been found in formulation containing Eranda. The HPLC analysis revealed the presence of shikimic acid, gallic acid, catechin in both formulations, but rutin has been found only in formulation containing Eranda.

Conclusion

From the results of experiments it has been observed that the formulation containing Eranda has more antioxidant activity as it contains more quantities of phenol, tannins, flavonoids, and flavonols than the formulation containing Gokshura.

How to cite this article

Ghildiyal S, Joshi A, Joshi VK. Comparative Study on Two Variants of Laghupanchamula (A Compound Ayurvedic Formulation) for Important Groups of Phytochemicals and Antioxidant Activity. J Drug Res Ayurvedic Sci 2017;2(3):157-163.

ORIGINAL ARTICLE

Siba P Rout, Channappa R Harisha

Pharmacognostical Evaluation of Raw and Shodhita (Processed) Danti [Baliospermum montanum (Willd.) Muell.-Arg] Root

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:11] [Pages No:164 - 174]

PDF  |  DOI: 10.5005/jp-journals-10059-0016  |  Open Access |  How to cite  | 

Abstract

Introduction

Danti, Baliospermum solanifolium (Burm.) Suresh [Syn. Baliospermum montanum (Willd.) Muell. Arg], of family Euphorbiaceae is an important herbal drug in the Ayurveda pharmacopoeia of India. In Ayurveda, Samskara (processing) has been shown to increase the efficacy of various drugs. Shodhana (purificatory measures/processing) is one of the steps involved in Samskara. The Charaka samhita describes the Shodhana (processing) of Danti by applying the fruit powder of Pippali (Piper longum L.) along with honey, wrapping it with Kusha (Desmostachya bippinnata Stapf.), and then fomenting it. The root thus obtained is dried under sunrays and then stored for further use. The exact pharmacognostical changes that transpire through Samskara (classical processing technique) remain to be explored scientifically. Hence, an attempt has been made to evaluate the pharmacognostical changes in Danti root, including its powder microscopy.

Materials and methods

Roots of raw Danti (RD) were collected from its natural habitat (Odisha) after proper botanical authentication. The roots were subjected to Shodhana and four groups of Danti root—RD, classically processed Danti root (CPDR), Kusha-processed Danti root (KPDR), and water-classically processed Danti root (WPDR)—were obtained. The raw and classically processed Danti roots were evaluated for their macroscopic and microscopic characters while RD, CPDR, KPDR, and WPDR were subjected to powder microscopy. The macroscopic powder images of the respective Danti samples was carried out by L*a*b*color-based image segmentation for identification.

Results

Transverse sections (TS) of CPDR show characteristic features with multilayered, ruptured reddish cork cells and presence of black debris of Pippali adhering to cork cells. Powder microscopy reveals Pippali with stone cells and dark-brownish oleoresin content in the CPDR group. WPDR reveals more swollen sclereids compared with the KPDR group. Macroscopic imaging showed distinct L*a*b* color-based segmentation.

Conclusion

Pharmacognostical findings of raw and shodhita Danti root will serve as a reference material for future scientific investigation.

How to cite this article

Rout SP, Harisha CR, Acharya R. Pharmacognostical Evaluation of Raw and Shodhita (Processed) Danti [Baliospermum montanum (Willd.) Muell.-Arg] Root. J Drug Res Ayurvedic Sci 2017;2(3):164-174.

ORIGINAL ARTICLE

Selim Mehmud, D Baruah, BK Bharali, GVR Joseph

Medico-ethnobotanical Claims used against Gastrointestinal Disorders by Different Tribes of Assam, India

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:8] [Pages No:175 - 182]

PDF  |  DOI: 10.5005/jp-journals-10059-0017  |  Open Access |  How to cite  | 

Abstract

Aim

The present communication deals with some newly reported Medico-ethnobotanical claims used for the treatment of various gastrointestinal disorders like blood dysentery, chronic dysentery, diarrhea, and cholera by using medicinal plants documented during field survey since last 3 years.

Materials and methods

Field surveys were conducted in different locations of Assam where many folk healers were interviewed for documentation of Medico-ethnobotanical information. The reported plants are collected, identified, and specimens are preserved.

Results

Nine different tribes and communities of Assam are newly recorded to use 30 medico-ethnobotanical claims for the concerned purpose, while use of similar claims is already reported elsewhere by other tribes of different regions; the other tribes using similar claim are highlighted. Out of total 47 medicinal plant specimens documented, 10 medicinal plants were recorded for 11 single formulations, 39 medicinal plants for 19 compound formulations, and among these 2 medicinal plants are repeated for both compound and single formulations.

Conclusion

Ethnic societies are still depending upon the medicinal plants for the treatment of various diseases including gastrointestinal disorders. Further scientific investigations are needed for validation of these folk claims.

Clinical significance

Cross-cultural study along with other tribes was done and highlighted against enumeration for further validation of folk claims.

How to cite this article

Bora D, Mehmud S, Baruah D, Bharali BK, Rath C, Mangal AK, Joseph GVR. Medico-ethnobotanical Claims used against Gastrointestinal Disorders by Different Tribes of Assam, India. J Drug Res Ayurvedic Sci 2017; 2(3):175-182.

REVIEW ARTICLE

Lalrinpuia Kawlni, Sachchida N Upadhyay

Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:5] [Pages No:183 - 187]

PDF  |  DOI: 10.5005/jp-journals-10059-0018  |  Open Access |  How to cite  | 

Abstract

Aim

This review aims to provide an up-to-date overview of pharmacological studies of Tithonia diversifolia (Hemsl.) A.Gray. Moreover, the focus of this review is the possible exploitation of this species to treat different diseases and to suggest future investigations.

Background

Tithonia diversifolia (Hemsl.) A.Gray is an important medicinal plant whose leaf is the major organ used alone or in combination with other plants for the treatment of a wide variety of ailments. This plant has been a subject of research interest because of its various indigenous medicinal uses in many countries.

Results

Different pharmacological studies on T. deversifolia show that it possesses antibacterial, antioxidant, anti-inflammatory, antinociception, analgesic, antidiarrheal, antimalarial, antihyperglycemic, and cancer chemopreventive activities due to the presence of different active constituents.

Conclusion

Tithonia diversifolia (Hemsl.) A.Gray extracts and their active constituents should be subjected to detailed mechanistic studies to fully understand the mode of action of the active constituents.

Clinical significance

Till date, there is no scientific literature/data regarding clinical trials of this plant except preclinical studies on different laboratory animals.

How to cite this article

Kawlni L, Bora M, Upadhyay SN, Hazra J. Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review. J Drug Res Ayurvedic Sci 2017;2(3):183-187.

REVIEW ARTICLE

Medico-Ethno Botanical Survey: An Overview of CCRAS Contributions

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:53] [Pages No:188 - 240]

PDF  |  DOI: 10.5005/jp-journals-10059-0019  |  Open Access |  How to cite  | 

Abstract

Aim

Medico-Ethno Botanical Survey (MEBS) was initiated by the Central Council for Research in Ayurvedic Sciences (CCRAS) in 1969 with the main aim of survey and documentation of medicinal plants of India used in Ayurveda system of medicine. Through its five peripheral institutes, namely Regional Ayurveda Research Institute for Metabolic Disorders (RARIMD)— Bengaluru, Regional Ayurveda Research Institute for Gastro-Intestinal Disorders (RARIGID)—Guwahati, Regional Ayurveda Research Institute (RARI)—Itanagar, RARI—Jhansi, and RARI—Ranikhet, the Council has surveyed every part of phytogeographic regions across the country, including the Andaman & Nicobar Islands and Lakshadweep. During these survey tours, various medicinal plants were collected and preserved as Herbarium and Museum specimens. The survey team collects and supplies authentic raw drug samples for studies under various projects inside and outside the Council, including the projects under Central Scheme of Ayurvedic Pharmacopoeia Committee (APC). Herbarium and Museum centers located in various institutes of CCRAS are being used as reference centers for UG/PG/M.Phil./Ph.D. students and researchers for correct identification/authentication of their plant specimens or raw drug materials. Further, the folk-claims collected during the exploration work provide lead for validation and effective development of drugs based on traditional knowledge and not from any codified system of medicine. Ayurvedic ancient texts also explain the importance of medicinal plant survey.

Materials and methods

The gross physical achievements including the beneficiaries of MEBS, details of forest divisions, medicinal plant species collected, and preparation of Herbarium specimens during the reporting period 1969 to 2016 were compiled, summarized, and presented based on the information available in the published monographs, technical reports, and annual reports of CCRAS.

Conclusion

India is rich in its diverse natural resources and treated as one of the biggest natural biodiversity countries of the world. The cultural diversity in the country is represented by many cultural groups, including the tribes and others. The contributions of CCRAS are significant in extending Medico-Ethno Botanical Program across the country and also preserving the valuable ethnomedical knowledge prevailing among tribal communities through systematic survey, identification, preservation, documentation, and validation of medicinal plants.

How to cite this article

Rath C, Susmitha B, Tripathi AK, Chincholikar MB, Mangal AK, Srikanth N. Medico-Ethno Botanical Survey: An Overview of CCRAS Contributions. J Drug Res Ayurvedic Sci 2017;2(3):188-240.

SHORT COMMUNICATION

Suggested Format for Documentation of Demographic Data, Living Conditions, and Health Status for Research-oriented Health Care Programs

[Year:2017] [Month:July-September] [Volume:2] [Number:3] [Pages:6] [Pages No:241 - 246]

PDF  |  DOI: 10.5005/jp-journals-10059-0020  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Maheswar T, Singh S, Singh R, Khanduri S, Ota S, Srikanth N. Suggested Format for Documentation of Demographic Data, Living Conditions, and Health Status for Research-oriented Health Care Programs. J Drug Res Ayurvedic Sci 2017;2(3):241-246.