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ORIGINAL ARTICLE
Year : 2021  |  Volume : 6  |  Issue : 4  |  Page : 218-238

Antiproliferative potential of Amalaki Rasayana and the effect of Butea monosperma (Lam.) Taub on the cytotoxicity


1 Chemical Sciences and Technology Division, CSIR—National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
2 Chemical Sciences and Technology Division, CSIR—National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, Kerala, India
3 Department of Rasasastra and Bhaishajya Kalpana, Government Ayurveda College, Thiruvananthapuram, Kerala, India

Correspondence Address:
Kokkuvayil V Radhakrishnan
Chemical Sciences and Technology Division, CSIR—NIIST, Thiruvananthapuram 695019, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdras.jdras_71_21

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BACKGROUND: Amalaki Rasayana is one of the prominent rejuvenating Rasayana described in Indian traditional Ayurvedic medicine for healthy aging. AIM: This work is focused on the comparative evaluation of the antiproliferative potential of AR, amla (a constituent), and Butea monosperma (BM; a component in the preparation) in the human cervix adenocarcinoma (HeLa) cell line and normal lung fibroblast (WI-38) cell lines. Also, we carried out the identification of phytoconstituents from the heartwood of BM. MATERIALS AND METHODS: Cell growth inhibitory effects of the extracts of AR, amla, and BM were carried out using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Isolation and characterization of compounds from BM were carried out using column chromatography and various spectroscopic techniques. RESULTS: AR exhibited a significant anticancer activity in HeLa cells compared to amla, and the Rasayana was found to be less cytotoxic toward normal cells. The results indicated an increase in the cytotoxicity to HeLa cells when amla is processed compared to AR in the heartwood of BM. The phytochemical investigation of BM revealed the presence of isoflavones as the major constituent. The isolated compounds were formononetin, daidzein, prunetin, lupiwighteone, afrormosin, erypoegin K, genistein, sterols β-sitosterol and stigmasterol and a monosaccharide d-mannitol. Erypoegin K, lupiwighteone, and d-mannitol were reported for the first time from this species and afrormosin was reported for the first time from the heartwood. CONCLUSIONS: Antiproliferative potential of AR was confirmed on cervical carcinoma. BM significantly enhances the therapeutic potential of AR, and AR could be an effective chemopreventive agent.


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