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ORIGINAL ARTICLE
Year : 2021  |  Volume : 6  |  Issue : 4  |  Page : 206-217

Shelf life evaluation of Vasaharitaki Avaleha and Vasaharitaki granules: An Ayurvedic polyherbal formulation with its modified dosage form


Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda (AIIA), New Delhi, India

Correspondence Address:
Neelam Matwan
Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda (AIIA), Mathura Road, Gautam Puri, Sarita Vihar, New Delhi 110076
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdras.jdras_67_21

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The stability of the product is its ability to resist deterioration due to environmental or microbial degradation, which is also called as shelf life, akaSaviryata Avadhi in Ayurveda. Vasaharitaki Avaleha (VHA) is a purely polyherbal formulation, which is mentioned for the management of various ailments of the respiratory system such as Shwasa (bronchial asthma) and Kasa (cough). There is always an issue regarding the palatability of this drug found in daily practices. Alteration or modification of the dosage form is a way to recover this problem without compromising the efficacy and stability of the drug. Therefore, this study was planned and the stability data of VHA and Vasaharitaki granules (VHG) is being presented based on primary physicochemical parameters (pH, loss on drying [LOD], extractive value, total sugar, total fat, and microbial count) and chromatographic fingerprinting as per International Council of Harmonization (ICH) Guidelines for Accelerated Study. The product withdrawn periods were 0, 1st, 3rd, and 6th months of storage in a condition of 40°C ± 2°C temperature and 75% ± 5% relative humidity. As per the current gazette notification, the shelf life of Avaleha and granules is not more than 3 years. On the basis of the accelerated stability data, 10% degradation of VHA was found in pH (3.312), LOD (11.088), total sugar (53.28), total fat (0.198), total plate count (378) parameters, and 10% degradation of VHG was found in pH (3.762), LOD (5.724), total sugar (63.702), water-soluble extractive (68.913), alcohol-soluble extractive (40.968), and total plate count (864.9). On the basis of these alterations, the stability period of VHA and VHG has been calculated to be 3.3 years and 2.8 years, respectively.


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