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VOLUME 5 , ISSUE 1 ( January-March, 2020 ) > List of Articles
YR Sanjaya Kumar, OS Lakshmi, N Thamizh Selvam, KG Vasanthakumar, Srikanth Ala, Sudesh N Gaidhani, G Kumara Swamy
Keywords : Ficus gibbosa Blume, Nicotinamide, Sprague Dawley rats, Streptozotocin,Antidiabetic
Citation Information : Kumar YS, Lakshmi O, Selvam NT, Vasanthakumar K, Ala S, Gaidhani SN, Swamy GK. Antidiabetic Activity of Ficus gibbosa Blume Extracts in Streptozotocin–Nicotinamide-induced Diabetes in Sprague Dawley Rats. J Drug Res Ayurvedic Sci 2020; 5 (1):57-62.
License: CC BY-NC 4.0
Published Online: 29-07-2020
Copyright Statement: Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.
Aim: To evaluate the antidiabetic activity of hydroalcoholic extracts of Ficus gibbosa Blume (leaves and stem bark) in streptozotocin–nicotinamide induced diabetic rats. Materials and methods: The animals were rendered diabetic by single intraperitoneal injections of nicotinamide (195 mg/kg body weight) followed by streptozotocin (65 mg/kg body weight). Induction of experimental diabetes was confirmed by blood glucose analysis. The test extracts were used at 3-dose levels viz., low dose (100 mg/kg body weight), average dose (250 mg/kg body weight and high dose (500 mg/kg body weight). Male Sprague Dawley rats were used in the experiment, each containing 6 animals. Oral glucose tolerance test was carried out 7 days post test extract administration at 3 doses. The diabetic animals were given the test extracts at different doses for a period of 5 weeks and blood sugar was evaluated at weekly intervals. Results: Both leaves and stem bark extracts of Ficus gibbosa Blume significantly reduced the elevated blood glucose levels at 60- and 120-minute postglucose overload. The test extracts showed significant antidiabetic activity against streptozotocin- and nicotinamide-induced diabetes in Sprague Dawley (SD) rats. Conclusion: The extracts of Ficus gibbosa Blume showed significant antidiabetic activity against experimental type 2 diabetes in SD rats.