Journal of Drug Research in Ayurvedic Sciences

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VOLUME 5 , ISSUE 1 ( January-March, 2020 ) > List of Articles


Evaluation of Quality Characteristics of Rasa-sindoor: An Ayurvedic Classical Rasa-aushadhi

Arjun Singh, Galib Ruknuddin, Sreedhar Bojja, Kartar S Dhiman

Keywords : Kupi Pakva procedure, Mercurial, Rasa-sindoor, Rasayoga, X-ray diffraction,Gandhaka

Citation Information : Singh A, Ruknuddin G, Bojja S, Dhiman KS. Evaluation of Quality Characteristics of Rasa-sindoor: An Ayurvedic Classical Rasa-aushadhi. J Drug Res Ayurvedic Sci 2020; 5 (1):25-31.

DOI: 10.5005/jdras-10059-0084

License: CC BY-NC 4.0

Published Online: 29-07-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Background: The word Rasa-sindoor was first mentioned in Rasendra Chintamani. Rasa-sindoor is therapeutically very effective and being indicated in various diseases. It is a mercury- and sulfur-based Rasaushadhis (herbomineral/metallic preparations) prepared by the Kupi Pakva procedure. Here an attempt has been made to prepare and understand its chemical composition. Objective: To develop quality standards of Rasa-sindoor prepared as per the procedures mentioned in the Ayurvedic classics. Materials and methods: The equal quantities of purified mercury and sulfur were placed in a khalva yantra. The mixture was levigated homogeneously, until a black powder was formed. This was further levigated to obtain black, soft, lusterless fine powder like collyrium (kajjali). Then Bhavana with vatankura swaras was given and bhavita Kajjali was filed in kancha kupi. Finally, Rasa-sindoor was collected from the neck of the Kupi. Physicochemical analysis, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and atomic absorption spectroscopy (AAS) have been performed to ensure the chemical nature. Results: The chemical analysis revealed that Rasa-sindoor contains 81.7% of mercury and 14.7% of sulfur on average together with other minor elements. Particle size showed the presence of microfine particle. Rasa-sindoor is tri/hexagonal (α-form) form of mercury sulfide and the XRD of the three samples confirms this phase. Usually prepared by the Kupi Pakva procedure, the free sulfur (as is in kajjali) is completely absent in the formulation. Conclusion: The results of this study certainly can be utilized as baseline data for quality assurance of this herbomineral formulation. The preliminary profiles of Rasa-sindoor evaluated in this attempt could be used to lay down a new set of pharmacopoeial standards for further research studies.

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