Citation Information :
Biswas R, Kanjilal S, Dey A, Mana S, Bhatt BN, Pandit S, Chakraborty P, Gandhi D, Maurya RP, Narwaria A, Maity S, Katiyar CK. Anti-inflammatory and Analgesic Activity of an Ayurvedic Liniment Formulation. J Drug Res Ayurvedic Sci 2018; 3 (2):113-118.
Aim: The objective of these studies was to assess the antiinflammatory and analgesic activity claim of an Ayurvedic liniment (ZRL) formulation prepared basis the wisdom of classical formulations.
Materials and methods: Carrageenan-induced paw edema was used to investigate the anti-inflammatory activity. Analgesic activity was examined using hot plate method and tail flick method. The efficacy of the topically applied ZRL formulation was evaluated vis-à-vis control.
Results: The percentage of reduction of paw volume after ZRL treatment and standard diclofenac Gel were 49.18 ± 2.12 and 81.79 ± 1.24 respectively. In Eddy\'s hot plate model, after a latency period of 2 hours following topical application of the ZRL formulation, there was a significant reduction (66%) to painful sensation compare to control. In tail flick method, 89% reduction to painful sensation was observed with respect to pretreatment.
Conclusion: The present study provided a scientific justification for pain relief and management of inflammation, by showing its peripheral and central acting anti-nociceptive and anti-inflammatory properties
Clinical significance: The present in vivo anti-inflammatory and analgesic activity of ZRL formulation showed its potential in the management of pain and inflammation associated with musculoskeletal disorders. The taila formulation is in clinical use for management of pain associated with musculoskeletal and neurological disorders.
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