Journal of Drug Research in Ayurvedic Sciences

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VOLUME 2 , ISSUE 4 ( 2017 ) > List of Articles

RESEARCH ARTICLE

Evaluation of Antidiabetic Potential of New Dosage Forms of AYUSH 82 in Streptozotocin-induced Type II Diabetic Rats

Manju Setia, Arun Gupta, Rajiv K Rai, Ankit Nigam

Citation Information : Setia M, Gupta A, Rai RK, Nigam A. Evaluation of Antidiabetic Potential of New Dosage Forms of AYUSH 82 in Streptozotocin-induced Type II Diabetic Rats. J Drug Res Ayurvedic Sci 2017; 2 (4):274-280.

DOI: 10.5005/jp-journals-10059-0023

License: CC BY-NC-SA 3.0

Published Online: 00-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: AYUSH 82 powder is an Ayurvedic antidiabetic formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India. The antidiabetic potential of AYUSH 82 powder along with its two new dosage forms—AYUSH 82 mixture extract and AYUSH 82 compound extract—has been established to be mediated via α-amylase inhibitory property, insulin-dependent glucose uptake in skeletal muscle cell line (C2C12 myotubes). Aim: In the current study, we investigated the in vivo antidiabetic potential of new dosage forms of AYUSH 82—AYUSH 82 mixture extract and AYUSH 82 mixture extract + Shilajit. Results and conclusion: Oral administration of AYUSH 82 mixture extract for 28 days twice daily could significantly increase serum insulin levels, reduction in Glucose Area under Curve 0 to 90 minutes, fed blood glucose, and triglyceride levels. It also showed improvement in histopathological grading, which resulted in protecting the pancreatic islets from progressive damage. Addition of Shilajit to AYUSH 82 mixture extract did not contribute much improvement in biochemical parameters related to diabetes.


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