Journal of Drug Research in Ayurvedic Sciences

Register      Login

VOLUME 2 , ISSUE 3 ( July-September, 2017 ) > List of Articles

REVIEW ARTICLE

Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review

Lalrinpuia Kawlni, Sachchida N Upadhyay

Citation Information : Kawlni L, Upadhyay SN. Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review. J Drug Res Ayurvedic Sci 2017; 2 (3):183-187.

DOI: 10.5005/jp-journals-10059-0018

License: CC BY 3.0

Published Online: 00-09-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

This review aims to provide an up-to-date overview of pharmacological studies of Tithonia diversifolia (Hemsl.) A.Gray. Moreover, the focus of this review is the possible exploitation of this species to treat different diseases and to suggest future investigations.

Background

Tithonia diversifolia (Hemsl.) A.Gray is an important medicinal plant whose leaf is the major organ used alone or in combination with other plants for the treatment of a wide variety of ailments. This plant has been a subject of research interest because of its various indigenous medicinal uses in many countries.

Results

Different pharmacological studies on T. deversifolia show that it possesses antibacterial, antioxidant, anti-inflammatory, antinociception, analgesic, antidiarrheal, antimalarial, antihyperglycemic, and cancer chemopreventive activities due to the presence of different active constituents.

Conclusion

Tithonia diversifolia (Hemsl.) A.Gray extracts and their active constituents should be subjected to detailed mechanistic studies to fully understand the mode of action of the active constituents.

Clinical significance

Till date, there is no scientific literature/data regarding clinical trials of this plant except preclinical studies on different laboratory animals.

How to cite this article

Kawlni L, Bora M, Upadhyay SN, Hazra J. Pharmacological Profile of Tithonia diversifolia (Hemsl.) A.Gray: A Comprehensive Review. J Drug Res Ayurvedic Sci 2017;2(3):183-187.


PDF Share
  1. Tithonia diversifolia. Natural Resources Conservation Service. Plants Database. USDA. Retrieved 11, December 2015.
  2. Agroforestry database: a tree reference and selection guide version 4; 2009.
  3. In vitro cytotoxicity studies of 20 plants used in the Nigerian antimalarial ethnomedicine. Phytomedicine 2006 Mar;13(4):295-298.
  4. Sesquiterpenes from the leaves of Tithonia diversifolia. J Nat Prod 1998 Jun 26;61(6):827-828.
  5. An artemisinic acid analogue from Tithonia diversifolia. Phytochemistry 1996 Feb;41(2):557-559.
  6. Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. J Ethnopharmacol 2004 Feb;90(2-3): 317-321.
  7. Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J Nat Prod 2002 Apr;65(4):532-536.
  8. Cytotoxic principles from leaves of Tithonia diversifolia. Chin Pharm J 2001;53:217-223.
  9. In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. J Neurooncol 1994;19(1):25-35.
  10. Antimicrobial effects of Tithonia diversifolia and Jathropa gosypifolia leaves extract collected from Ogbomoso, Oyo State. Nigeria. Adv Nat Appl Sci 2007;4(1):31-54.
  11. Bacteria in biology, biotechnology and medicine. 4th ed. New York: John Wiley and Sons Ltd; 1999.
  12. Tithonia diversifolia as a grren manure for soil fertility improvement in Western Kenya: a review. Agrofor Syst 2000 Jul;49(2):201-221.
  13. Tithonia diversifolia (Hemsley) A. Gray. Pesticidal Plant Leaflet. World Agroforestry Centre, Nairobi, Kenya; 2013. ISBN: 978-92-9059-347-348.
  14. Phytochemical and Antimicrobial Studies of Extracts from the Leaves of Tithonia Diversifolia for Pharmaceutical Importance. J Pharm Biol Sci 2013;6(4):21-25.
  15. Antioxidant effect of plant extracts of the leaves of Tithonia diversifolia (Hemsl.) A. Gray on the free radical DPPH. J Chem Pharm Res 2016;8(8):1182-1189.
  16. Anti-inflammatory and Analgesic potential of aqueous leaf extract of Tithonia diversifolia in rodents. J Nat Sci Eng Tech 2014;13(1):82-90.
  17. Studies of phytochemical screening, acute toxicity and anti-diarrhoeal effect of aqueous extract of Kenyan Tithonia diversifolia leaves in rats. Br J Pharmacol Toxicol 2012;3(3):127-134.
  18. Anti-malarial and repellent activities of Tithonia diversifolia (Hemsl.) leaf extracts. J Med Plants Res 2008;2(8):171-175.
  19. In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: Tagitinin C Thieme. J Plant Med 2002;68(6):543-545.
  20. Antioxidant and Hypoglycemic Effects of Tithonia diversifolia aqueous leaves extract in alloxan-induced diabetic mice. Adv Environ Biol 2013;7(9):2116-2125.
PDF Share