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1.  Research Article
In vitro Studies on Antidiabetic Potential of New Dosage Forms of AYUSH 82
M Setia, K Meena, A Madaan, Narayanam Srikanth, Kartar S Dhiman, JLN Sastry
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:1-9] [No of Hits : 313]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0001 | FREE

ABSTRACT

AYUSH 82 powder is an Ayurvedic antidiabetic formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India. It comprises ingredients traditionally used for their beneficial effect in diabetes (Prameha/Madhumeha). The hypoglycemic effects of AYUSH 82 powder have been reported in diabetic subjects. In the current study, the antidiabetic potential of AYUSH 82 powder along with its two new dosage forms - AYUSH 82 mixture extract and AYUSH 82 compound extractwas investigated in vitro for elucidating mechanism of their action by possible α-amylase inhibitory property, insulindependent glucose uptake in skeletal muscle cell line (C2C12 myotubes), and effect on peroxisome proliferator-activated receptor gamma (PPAR-γ) activity.

All the three dosage forms of AYUSH 82 - powder, mixture extract, and compound extract - exhibited inhibition of á-amylase activity. AYUSH 82 mixture extract, however, demonstrated highest extent of inhibition in both methanolic (87.4%) and aqueous (48.2%) format. All the three dosage forms of AYUSH 82 also demonstrated an increase in insulin-dependent glucose uptake in C2C12 myotubes as compared with control. However, none of the test items (TIs) exhibited activation of PPAR-γ expression in tested ranges, indicating that antidiabetic potential of TIs may not be mediated via PPAR-γ activation. Results indicated that the new dosage forms of AYUSH 82 (mixture extract and compound extract) may be useful for making new dosage forms of AYUSH 82 as tablets/capsule, etc.

Keywords: α -Amylase, A ntidiabetic a ctivity, A YUSH 82 powder, Compound extract, Glucose uptake assay, Mixture extract, Peroxisome proliferator-activated receptor gamma

How to cite this article: Setia M, Meena K, Madaan A, Srikanth N, Dhiman KS, Sastry JLN. In vitro Studies on Antidiabetic Potential of New Dosage Forms of AYUSH 82. J Drug Res Ayurvedic Sci 2017;2(1):1-9.

Source of support: Nil

Conflict of interest: None

 
2.  Research Article
Utilization of Some Important Herbs used as “Śāka” (Vegetable) in Ayurveda by Tribal People of Raigarh District, Chhattisgarh State, India
Sanjeev Kumar Lale, Sugriv Kumar Gaur
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:40-49] [No of Hits : 307]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0007 | FREE

ABSTRACT

There are a large number of classical Ayurvedic plants that are used as vegetables by tribal communities of Raigarh district. These plants profusely grow on wastelands that are free of insecticides/pesticides and give new relish vegetables. These vegetables are not popular among common people or they feel inferior to accept these vegetables in their diet. The consumption of such important plant resources should be popularized as they could be beneficial resource for prevention, management, and treatment of chronic diseases. The present study deals with the medicobotanical survey work of Dharmajaygarh and Raigarh forest divisions of Raigarh district, Chhattisgarh, India. These vegetables are arranged in their useful part, e.g., leaf, fruit, tuber, etc., their Ayurvedic name, local name, botanical name, family, and part used followed by their Ayurvedic and local uses. The study revealed the utilization of 31 classical Ayurvedic vegetables (saka) by tribal people of Raigarh district. Vegetables like Enhydra fluctuans Lour., Corchorus capsularis L., Leucas cephalotes (Roth) Spreng., Boerhavia diffusa L., Senna tora (L.) Roxb., Celosia argentea L., Lathyrus sativus L., Centella asiatica (L.) Urb., Tamilnadia uliginosa (Retz.) Tirveng. & Sastre, Dioscorea alata L., etc., are unique in this area. The study suggests that the inclusion of these herbs in the regular diet of common people helps in prevention and management of various ailments.

Keywords: Ayurveda, Herbs, Raigarh district, Śāka, Vegetable.

How to cite this article: Lale SK, Gaur SK. Utilization of Some Important Herbs used as “Śāka” (Vegetable) in Ayurveda by Tribal People of Raigarh District, Chhattisgarh State, India. J Drug Res Ayurvedic Sci 2017;2(1):40-49.

Source of support: Nil

Conflict of interest: None

 
3.  Research Article
Concept of Stability Study of Churna Kalpana
Neetu, Harish K Singhal, Khem Chand Sharma
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:34-39] [No of Hits : 258]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0006 | FREE

ABSTRACT

A common myth exists among people that Ayurvedic medicines do not have an expiry date, but it is not true. Concept behind expiry means that after a certain period, the substance that is used as medicine undergoes changes, which make it ineffective. That period is known as expiry date or shelf life in modern system of medicine. This concept was described in 14th century by Acharya Sharangdhar as Saviryata Awadhi in his textbook Sharangdhar Samhita. Recent development in the field of Ayurvedic pharma industries has reestablished old principles through evidences. Among the description of all five primary dosage forms, Churna (powder) has been considered in this study. There are numerous factors that affect its shelf life, which have been discussed in this study. Based on that, we conclude that by improving storage conditions, adding additives and preservatives, degradation of Churna can be checked.

Keywords: Churna, Shelf life, Stability.

How to cite this article: Neetu, Singhal HK, Sharma KC. Concept of Stability Study of Churna Kalpana. J Drug Res Ayurvedic Sci 2017;2(1):34-39.

Source of support: Nil

Conflict of interest: None

 
4.  Editorial
Editorial
Prof Vd Kartar Singh Dhiman
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:iv] [No of Hits : 251]
Full Text PDF | Abstract | FREE

ABSTRACT

In the emerging scenario, there has been tremendous expansion in the use of Ayurveda and traditional system of medicines not only in the developing countries but also in the developed countries owing to its efficacy and potentials of prevention and health promotion.

 
5.  Research Article
Microscopical and Preliminary Physicochemical Studies of Two Important Endangered Ayurvedic Medicinal Plants Kutki and Trayamana to establish their Identity
Anupam K Mangal, Chinmay Rath, Devesh Tewari, Sreya Dutta, Narayanam Srikanth, Kartar S Dhiman
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:18-22] [No of Hits : 191]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0003 | FREE

ABSTRACT

Kutki is an important Ayurvedic drug native to the Himalayan region, and its official source is Picrorhiza kurroa Royle ex Benth., belonging to the family Scrophulariaceae. The plant is a small, hairy perennial herb with creeping and woody rhizome and used in various Ayurvedic medicines. It is useful as a laxative, liverstimulant, galactogouge, and appetite-stimulant and is beneficial in bronchial asthma. Due to its high demand, the plant is often adulterated/substituted with the roots of Trayamana (Gentiana kurroo Royle), as one of the source of the Kutki. The present study has focused to establish the identity of Picrorhiza kurroa Royle ex Benth through microscopical investigations and comparison of the genuine drug with its substitute Gentiana kurroo Royle. Powder of the rhizomes of Picrorhiza kurroa Royle ex Benth. and roots of Gentiana kurroo Royle were subjected to microscopic characterization and physicochemical analysis, which would not only serve in the identification of both the drugs, but also contribute toward establishing pharmacopoeial standards.

Keywords: Ayurvedic, Endangered, High altitude, Kutaki, Microscopy, Rhizomes, Trayamana.

How to cite this article: Mangal AK, Rath C, Tewari D, Dutta S, Srikanth N, Dhiman KS. Microscopical and Preliminary Physicochemical Studies of Two Important Endangered Ayurvedic Medicinal Plants Kutki and Trayamana to establish their Identity. J Drug Res Ayurvedic Sci 2017;2(1):18-22.

Source of support: Nil

Conflict of interest: None

 
6.  Research Article
Pharmacognostical and Histochemical Studies on Apakva Kadali (Unripe Banana Fruit): Musa × paradisiaca L.
Shantha T Ramasheshan, Prathapa R Maramreddy, Patchaimal Pitchaiah, Kishore K Ramakrishana, Vandana Bharti, Venkateshwarlu Gaddam, Devesh Tewari, Anupam K Mangal, Narayanam Srikanth, Kartar S Dhiman
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:10-17] [No of Hits : 186]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0002 | FREE

ABSTRACT

The unripe fruit of Musa × paradisiaca L., classically known as apakva kadali, belonging to the family Musaceae, is used as pathya in atisara (diarrhea), in grahani (irritable bowel syndrome), and agnimandya (loss of appetite). The unripe fruits are considered to be helpful in the management of diabetes mellitus. Being an important medicinal plant, the present investigation is an attempt to explore the pharmacognostical analysis and thin-layer chromatography fingerprint studies on the widely used Musa. × paradisiaca L. The studies revealed that unripe banana fruit showed the presence of small outer protrusion of papillae on the epidermis, abundant tannin-containing cells in the epicarp and mesocarp. Elongated air-spaced cells are surrounded by the parenchyma cells in the epicarp, abundant starch grains in the mesocarp portion, and acicular crystals of calcium oxalate in raphide bundles. To detect the location of various constituents of the drug, sections of unripe fruits were treated with various reagents, and studies showed the presence of phenols, protein, calcium oxalate, magnesium, starch, cellulose, calcium pectate, lignin, sulfated mucopolysaccharides, tannin, and silica contents. Phytochemical studies showed the presence of alkaloids, carbohydrates, phenols, proteins, starch, tannins, steroids, and saponins.

Keywords: Antidiabetic, Histochemical, Microscopy, Musa paradisiaca, Phytochemical, Unripe fruit.

How to cite this article: Ramasheshan ST, Maramreddy PR, Pitchaiah P, Ramakrishana KK, Bharti V, Gaddam V, Tewari D, Mangal AK, Srikanth N, Dhiman KS. Pharmacognostical and Histochemical Studies on Apakva Kadali (Unripe Banana Fruit): Musa × paradisiaca L. J Drug Res Ayurvedic Sci 2017;2(1):10-17.

Source of support: Nil

Conflict of interest: None

 
7.  Research Article
Micrometric Study and Random Amplified Polymorphic Deoxyribonucleic Acid Analysis of Wattakaka volubilis (Linn. f.) Stapf. Leaves
Raghavendra Naik, CR Harisha, Rabinarayan Acharya
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:23-29] [No of Hits : 165]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0004 | FREE

ABSTRACT

The leaves of Jīvantī are considered to be the best among the vegetables in the classical texts of Ayurveda. In some parts of India, Wattakaka volubilis (Linn. f.) Stapf. is used in the name of Jīvantī for treatment of pyoderma, fever, cough, cold, rheumatic pain, diabetes, eye diseases, snake bite etc. The present study deals with the micrometric evaluation and molecular characterization of Wattakaka volubilis (Linn. f.) Stapf. leaves by random amplified polymorphic deoxyribonucleic acid (RAPD) markers by following standard parameters. Morphological study showed that leaves are 6.5.14 × 4.5.11 cm, in size, broadly ovate or suborbicular with reticulate venation. Transverse section of petiole measures about 2.7 μm, showing single-layered epidermis with multicellular, warty trichomes. Cortex contains chloroplast and several prismatic and rosette crystals. Section through midrib measures about 3.4 × 3.2 μm, having centrally located bicollateral vascular bundle supported by ground tissue. Powder microscopy showed the presence of multicellular and glandular trichomes, paracytic stomata, rosette crystals of calcium oxalate, oil globules and chlorophyll pigments. In RAPD analysis, all the 10 primers showed good amplification. The unique bright and light bands obtained in polymerase chain reaction amplification along with quantitative pharmacognostical characters can be considered as a measure for authentication and standardization of the plant.

Keywords: Jīvantī, Pharmacognosy, Random amplified polymorphic deoxyribonucleic acid analysis, Wattakaka volubilis (Linn. f.) Stapf.

How to cite this article: Naik R, Harisha CR, A charya R . Micrometric Study and Random Amplified Polymorphic Deoxyribonucleic Acid Analysis of Wattakaka volubilis (Linn. f.) Stapf. Leaves. J Drug Res Ayurvedic Sci 2017;2(1):23-29.

Source of support: Nil

Conflict of interest: None

 
8.  Research Article
Influence of Farm Yard Manure, Farm Yard Manure + Urea, and Urea on Crop Yield in Prishnaparni (Uraria picta Desv. ex DC.)
Usha Kiran
[Year:2017] [Month:January-March] [Volume:2 ] [Number:1] [Pages:49] [Pages No:30-33] [No of Hits : 105]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10059-0005 | FREE

ABSTRACT

To evaluate the effect of farm yard manure (FYM) alone, FYM + urea, and urea alone on the growth and yield of Uraria picta Desv. ex DC. with two physicochemically different soils of Bundelkhand region, pot experiment was conducted during 2010 to 2011 and 2014 to 2015. FYM + urea applied in 50:50 ratio of nitrogen (N) gave best results as compared with the other treatments for crop yield in both the types of soils. Highest dry matter yield of 18.62 gm/pot was obtained during the year 2010 to 2011 and 24.33 gm/pot was obtained during the year 2014 to 2015 when FYM + urea was treated in black soil. The FYM alone and urea alone yielded dry matter of 16.03 gm/pot and 15.55 gm/pot respectively, during the year 2010 to 2011. Trends for the increase in dry matter yield were similar during both the years of study. In red soil also, dry matter yield was highest (10.23 gm/ pot) during the year 2010 to 2011 and (14.33 gm/pot) 2014 to 2015 when FYM + urea was applied. The FYM + urea in 50:50 ratio is the best for the growth of Uraria picta. Desv. ex DC.

Keywords: Crop yield, Dry matter, Farm yard manure + urea, Nitrogen, Soil, Uraria picta Desv. ex DC.

How to cite this article: Kiran U. Influence of Farm Yard Manure, Farm Yard Manure + Urea, and Urea on Crop Yield in Prashnaparni (Uraria picta Desv. ex DC.). J Drug Res Ayurvedic Sci 2017;2(1):30-33.

Source of support: Nil

Conflict of interest: None

 
9.  Particular
Medicinal Plants Wealth of Rewa Forest Division of Madhya Pradesh State
Sugriv Kumar Gaur and Sanjeev Kumar Lale
[Year:2016] [Month:October-June] [Volume:1 ] [Number:2] [Pages:92] [Pages No:47-72] [No of Hits : 71]
Full Text PDF | FREE

 
10.  Particular
Powder Microscopy and TLC Profiles of Some Stem and Stem Bark Drugs used in Ayurveda
A.G. Mhase, V.M. Dhanorkar, A.M. Gurav, B.P. Dhar and G.S. Lavekar
[Year:2016] [Month:October-June] [Volume:1 ] [Number:2] [Pages:92] [Pages No:1-12] [No of Hits : 61]
Full Text PDF | FREE

 
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